Acne resistance issues: solutions

Acne is one of the most common dermatoses, especially among young people. The worldwide prevalence reaches up to 80% people aged 15 17 who have symptoms acne, and condition often persists into adulthood. In pathogenesis in addition pathological hyperkeratosis inflammation, an important role played by such factors as massive microbial contamination, species composition, biological properties pathogens, particular, their drug resistance. For treatment acne moderate severe severity, antibacterial drugs are used – tetracycline, erythromycin, doxycycline. These a bacteriostatic effect on Cutibacterium acnes inhibiting synthesis bacterial proteins. Antibiotics for demonstrate antimicrobial anti-inflammatory effects act two directions: they reduce colonization C. inhibit production inflammatory mediators associated with С . Side antibiotic rare, but main problem appointment resistance, frequency which increasing every year. review part article presents literature data domestic foreign authors formation resistance therapy patients process evolution. Cause-and-effect relationships application various classes described. strategy tactics doctor limit spread considered. A special place given benzoyl peroxide, clindamycin synergistic fixed combination / peroxide overcoming achieving effectiveness safety therapy. second our own clinical observations combined preparation Klindavit Combo gel (clindamycin peroxide) papulopustular outpatient dermatologist.